托吡酯对缺血性脑损伤的神经保护作用

The Neuroprotection of Topiramate against Cerebral Ischemic Injury

缺血性脑损害的病理生理机制涉及许多方面。最近的动物实验发现,抗癫药托吡酯具有一定的神经保护作用,可通过多种途径减轻缺血性神经元损伤,并且具有良好的耐受性和血脑屏障通透性,有望作为一种有效的神经保护药应用于临床。

The pathophysiological mechanisms of cerebral ischemia injury involved in many aspects. Recent animal experiments have demonstrated that topiramate, an anti-epilepsy drug,has certain neuroprotective effects. It can reduce ischemic neuronal injury through various pathways, and has good tolerance and permeability of blood-brain barrier. As an effective neuroprotective agent, topiramate is promising in clinical application.