NF-κB及ICAM-1在非小细胞肺癌中的表达及其临床意义

Expression and clinical significance of NF-κB and ICAM-1 in non-small cell lung cancer

目的探讨核因子NF-κB(nuclear factoro fkappa B,NF-κB)及细胞间粘附分子-1(intercellul aradhesionmo lecule-1,ICAM-1)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义。方法采用免疫组织化学SABC技术,检测NF-κBp65及ICAM-1在40例非小细胞肺癌石蜡包埋组织标本中的表达,并比较二者与临床多种因素(包括性别、年龄、组织学类型、分化程度、瘤体大小、TNM分期、吸烟指数及远处转移)的关系,以40例肺部非恶性组织标本为对照。结果肺癌组织中NF-κBp65及ICAM-1的表达明显高于其在非恶性肺组织中的表达(P<0.01)。肺癌组织中NF-κBp65和ICAM-1在腺癌中的表达明显高于鳞癌(P<0.01);ICAM-1在低分化肺癌组织中的表达比在高-中分化组织中显著增强(P<0.05);NF-κBp65和ICAM-1的表达在有远处转移时比无远处转移时显著性增强(P<0.01);而在不同年龄、性别、瘤体大小、临床分期及吸烟指数的肺癌组织中NF-κBp65和ICAM-1的表达没有显著性差异(P>0.05);非小细胞肺癌组织中NF-κBp65的表达与ICAM-1的表达呈正相关(P<0.01)。结论NF-κBp65及ICAM-1在非小细胞肺癌中有高表达;且其表达与肺癌的浸润转移密切相关;同时在非小细胞肺癌组织中NF-κBp65的表达与ICAM-1的表达呈正相关。

[ Objective] To investigate the clinical significance of NF-kB and ICAM-1 in non-small cell lung cancer （NSCLC）. [Methods] The expression of NF-KBp65 and ICAM-1 were detected by SABC immunohisto chemistry method in paraiffin-embeded sample from 40 cases of NSCLC to analyzed the correlation between NF-kBp65, ICAM-1 and kinds of clinical factors（including sex, age, histological type, ceil differentiation, tumor size,TNM stage, cigarette index and distant metastasis）. 40 cases of non-malignant tissue from lung lesions were employed as a control group. [Results] NF-KBp65 and ICAM-1 were evidently expressed and were more strongly expressed in lung cancer than in non-malignant tissue （P 〈0.05）. In lung cancer, the expression of NF-kBp65 and ICAM-1 in adenocareinoma was stronger than in squamous cell carcinoma. The expression of ICAM-1 in poorly differentiated tumor tissues was stronger than in well differentiated tumor tissues （P 〈0.05）. NF-kBp65 and ICAM-1 were more strongly expressed in lung cancer with distant metastasis than those without distant metastasis （P 〈0.05）.The expression of NF-kBp65 and ICAM-1 were not related to age, sex, tumor size, stage and cigarette index （P 〉0.05）. In NSCLC tissue, there was positive correlation between NF-kBp65 and ICAM-1 （P〈0.05）. [Conclusions] It was strongly expressed the expression of NF-kBp65 and ICAM-1. The expression of NF-kBp65 and ICAM-1 had relation with the invasion and metastasis of lung cancer. And in NSCLC tissue, there was positive correlation between NF-kBp65 and ICAM-1.