肿瘤特异性生长因子在子宫内膜癌的应用价值

Clinical value of TSGF in carcinoma of endometrium

目的探讨血清TSGF检测对子宫内膜癌的应用价值。方法对37例子宫内膜癌患者术前外周血及术中子宫静脉血中TSGF进行检测,并与CA125、cy21-1比较。结果子宫内膜癌患者血清TSGF含量及阳性率明显升高,敏感性为64.9%,特异性为62.5%;与术前外周血相比,术中子宫静脉血TSGF含量明显升高(P<0.05),阳性率略有上升;随着病理分级及临床期别的升高,血清TSGF含量呈上升的趋势;TSGF和CA125联合检测,敏感性可由单项TSGF的64.9%、CA125的29.7%提高到75.7%,特异性没有明显下降。结论血清TSGF检测对子宫内膜癌具有一定的诊断价值,癌旁静脉血TSGF升高更为明显,并与病理分级及临床期别有一定关系,TSGF+CA125联合检测具有更高的诊断价值。

[Objective] To estimate the clinical value of tumor specific growth factor （TSGF） in the diagnosis and monitoring of Carcinoma of Endometrium. [Methods] We collected the peripheral veins and uterine veins of the patients of Carcinoma of Endometrium, and examined the level of TSGF, then compared with CA125 and cy21-1.[Results] The level and the positive rate of TSGF for Carcinoma of Endometrium was significantly higher than other group （P 〈0.05）. The sensitivity and specificity were 64.9% and 62.5% resepectivily. Compared with the peripheral veins, the level of TSGF in the uterine veins was much higher （P 〈0.05）, and the positive rate increased appreciably.The serum level of TSGF correlated with histologic grades and the stages. The sensitivity of combining TSGF and CA125 was 75.7%, and it was better than TSGF or CA125 alone. [Conclusions] Serum TSGF level is helpful in diagnosis of Carcinoma of Endometrium, and is related with differentiation and clinical-stage. Combining TSGF and CA125 can improve the diagnostic sensitivity of Carcinoma of Endometrium.