利培酮与舒必利治疗急性脑血管疾病后妄想综合征比较

Risperidone vs sulpiride in treating delusional syndrome after acute cerebral vascular disease

目的:观察利培酮治疗急性脑血管疾病后妄想综合征的疗效。方法:急性脑血管疾病后妄想综合征病人100例,分为2组,利培酮组50例,男性27例,女性23例,年龄(64±s11)a,给予利培酮0.5mg·d-1,逐渐加至1.5～2.0mg·d-1,po×4wk;舒必利组50例,男性26例,女性24例,年龄(65±12)a,给予舒必利0.3g·d-1,逐渐加至0.5～0.6g·d-1,po×4wk。结果:利培酮组和舒必利组经过4wk的治疗后总有效率分别为86%和82%(P>0.05),2组在wk2末有效率分别为74%和24%(P<0.05)。结论:利培酮治疗急性脑血管疾病后妄想综合征与舒必利对比显效早、药物不良反应少且轻。

AIM： To observe the effects of risperidone for curing delusions syndrome after acute cerebral vascular diseasel （ACVD）. METHODS： One hundred patients with ACVD were divided into two groups ; risperidone groupconsisting 50 patients，M 27, F 23, age （64 ± s 11 ） a, were given risperidone 0.5 mg· d^ -1 with gradual increase dosage of 1. 5-2.0 mg· d^-1,po × 4 wk; sulpiride group of 50 patients, M 26, F 24, age （65 ± 12） a, were given sulpiride 0.3 g · d^ -1 also with gradual increase of dosage into 0.5-0.6 g · d^-1, po × 4 wk. RESULTS：After 4 wk, the general effective rates of risperidone group and sulpiride group were 86 % and 82 % ,respectively （P 〉0.05） , those of two groups by the end of 2 wk were 74 % and 24 %,respectively （P 〈0.05）.CONCLUSION：Delusional syndrome disappearing after ACVD with risperidone is earlier than sulpiride with more effective results and less adverse reactions.