持续静脉滴注奥曲肽防治重症急性胰腺炎并发症

Octreotide reduces the complications of severe acute pancreatitis(SAP) patients

目的观察奥曲肽对重症急性胰腺炎(SAP)并发症的防治作用.方法将68例SAP住院患者随机分为治疗组(n=36)及对照组(n=32),两组均采用传统的内科保守疗法,但治疗组加用奥曲肽50 μg/h,持续静脉滴注8～10 d,比较两组病例发生胸腔积液、肺炎、高血糖、假性胰腺囊肿的情况.结果治疗组胸腔积液、肺炎、高血糖、假性胰腺囊肿等并发症发生率明显低于对照组(P＜0.05).结论奥曲肽可降低SAP并发症发生率,减少外科手术的机会.

Objective To explore the prevertion and care effect of octreotide on complications of SAP. Methods Sixty-eight cases with SAP were divided into therapeutic group（n=36） and control group（n=32） randomly.All cases of two groups accepted conventional therapy. Therpeutic group accepted intra-venous octreotide therapy（50μg/h） for 8 to 10 days in addition. The complications of pleural effusion, pneumonia, hyperglycemia, pseudocyst of prancrease between the two groups were compared. Results The complications of pleural effusion,pneumonia, hyperglycemia, pseudocyst of prancrease in therapeutic were significantly lower than that in contrast group（P〈0.05）.Conclusion The application of octreotide in SAP patients declines the complications of pleural effusion ,pneumonia hyperglycemia,pseudocgst of pancrease and chance of surgical therapy.