曲美他嗪对急性心肌梗死梗死面积的影响

Clinical study on effect of infarct size by trimetazidine

目的通过QRS记分法观察急性心肌梗死(AMI)患者心电图QRS分值的动态变化,探讨曲美他嗪对梗死面积的影响。方法182例急性心肌梗死患者随机分为曲美他嗪治疗组(92例)及空白对照组(90例),计算并比较两组患者在治疗前、治疗后第7天及第30天QRS分值的变化情况。结果治疗组及对照组治疗前QRS分值差异无显著意义。治疗组在梗死7d后心电图QRS分值与治疗前差异无显著意义(P>0·05),但30d后QRS分值明显低于治疗前(P<0·05)。对照组在梗死7d及30d后心电图QRS分值均明显高于治疗前(P<0·05)。结论曲美他嗪能显著限制并缩小梗死面积,疗效显著优于常规药物治疗。

Objective To observe the change of electrocardiogram＇s QRS scores on AMI by QRS scoring system,then ro study the effect of trimetazidine（TMZ） on infarct size. Methods 182 patients with AMI were randomizedly divided to TMZ group（n=92） and control group（n=90）. Observed the changes of electrocardiogram in all patients after the treatments of TMZ or not, then calculated and compared the QRS scores between the two groups. Results The QRS scores of TMZ group in the seventh day were not changed significantly,but in the thirtieth day the QRS scores were significantly less than those in the first day when the patients were admitted（P〈0.05）. While the QRS scores of control group in the seventh day and in the thirtieth day were significantly higher than those in the first day when the patients were admitted. And the QRS scores of TMZ group in the seventh day and in the thirtieth day were significantly less than those of the control group. Conclusion The treatment of TMZ can markedly limit and decrease the infarct size.