瞬态诱发耳声发射用于黄疸新生儿的听力筛查

Application of transient evoked otoacoustic emission to jaundiced neonate's hearing screen

目的探讨瞬态诱发耳声发射(TEOAE)应用于新生儿黄疸听力筛查的临床意义。方法采用前瞻性队列研究方法对277例黄疸新生儿及50例健康新生儿进行TEOAE检测,出院前和出生后3个月复查。结果初查时黄疸新生儿TEOAE通过率为64·23%,健康新生儿TEOAE通过率为96%,两组检出率比较,差异有非常显著意义(P<0·01)。第1次复查黄疸新生儿TEOAE通过率为88%,第2次复查通过率为100%。结论TEOAE是快速可行的高危新生儿听力筛查方法,新生儿测试耳TEOAE的通过率与黄疸严重程度有关,黄疸对耳蜗的影响是可逆的。

Objective To investigate the feasibifity and clinical significance of hearing screening in jaundiced neonates by transient evoked otoaeoustie ernission（TEOAE）. Methods 277 jaundiced neonates under intensive care had been tested by TEOAE 2 or 3 time（ i. e. immediately after birth, before leaving hospital ,3 month later）. The results were compared with those of 50 healthy neonates using prospective cohort. Results The presence of TEOAE in jaundiced neonates was 64.23% in the first test, while in healthy neonates was 96%. Obviously, there was a significant difference in the statistical analysis. In the retest before their leaving the hospital,the presence of TEOAE in jaundiced neonates was 88% and in the retest 3 months later, the result was 100%. There was statistical significance between two groups（P〈0.01）. Conclusions The TEOAE test has been found to be practical and qniek enough to be performed in high-risk neonates;jaundice can cause hearing loss of neonates and the presence of TEOAE is closely related to its degree; but the influeree of jaundice on cochlear is reversible.