血清HA,PCⅢ,Ⅳ-C,LN联合PLD检测对肝硬化诊断价值的探讨

Study on the diagnostic value of serum hyaluronic acid,precollagen type Ⅲ,HA,colagen type Ⅳ,laminin and procollagen type Ⅲ concentrations for liver cirrhosis

目的:探讨透明质酸、型前胶原、型胶原、层黏连蛋白和脯氨酸肽酶对肝硬化的诊断价值。方法:采用放射免疫分析法和微量法对84例肝硬化患者血清中上述五项指标的代谢变化进行观察,并对结果进行分析。结果:与正常人相比,肝硬化和肝硬化腹水患者血清透明质酸、型前胶原、型胶原、层黏连蛋白和脯氨酸肽酶水平明显增高(P<0.01),脯氨酸肽酶与透明质酸、型前胶原、型胶原、层黏连蛋白之间有相关性。结论:血清透明质酸、型前胶原、型胶原、层黏连蛋白和脯氨酸肽酶等指标均能较好地反映肝纤维化的活动水平及程度。

Objective To investigate the diagnostic value of serum levels of hyaluronic acid, precollagen type Ⅲ , colagen type Ⅳ ,laminin and prolidase for liver cirrhosis. Methods Serum levels of colyentype Ⅳ ,precollagen type Ⅲ ,hyaluronic acid,laminin and prolidase were measured with radioimmunity analysis and micromethod in 20 controls and 84 patients with liver cirrhosis. Results Serum levels of hyaluronic acid,precollagen type Ⅲ ,colagen type Ⅳ ,laminin and prolidase were significantly higher in patients with liver cirrhosis than those in controls （P〈0. 01）. Serum level of prodidase was positively correlated with hypaluronic acid, precollagen type, Ⅲ, collagen type to and laminin. Conclusion Serum levels of these markers can reflect the degree of hepatic fibrosis and severity of liver damage.