来比林-吗啡复合液用于术后硬膜外自控镇痛的对比研究

Comparison study on Aspirin-DL-Lysine combined with Morphine used in postoperative epidural space self control analgesia

目的:观察来比林-吗啡复合液用于术后硬膜外自控镇痛时的疗效和不良反应。方法:90例妇科手术患者随机分为3组,术后分别采用单纯来比林(L)、单纯吗啡(M)和来比林-吗啡复合液(L-M)行硬膜外自控镇痛治疗,观察各组药物需求量、视觉模拟疼痛评分、体温、以及不良反应的发生率。结果:3组均达到完善的镇痛效果,对体温均无明显影响(P>0.05);L组0～24h药物需求量最多(P<0.01,P<0.05),L-M组与M组接近(P>0.05);M组恶心、呕吐、皮肤瘙痒等不良反应发生率最高(P<0.05),L-M组与L组接近(P>0.05)。结论:来比林-吗啡复合液用于术后硬膜外自控镇痛既能保证完善的镇痛效果,又能明显减少不良反应的发生。

Objective To observe the therapeutic effect and side effect of Aspirin-DL-Lysine and Morphine compound liquid used in postoperative peridural self control analgesia. Methods Gynecological patients were divided into 3 groups randomly. After operation, patients underwent peridural self control analgesia treated by Aspirin-DL-Lysine（group L）, Morphine （group M） and Aspirin combined Morphine （group L-M） respectively. The side effect, body temperature, visual imitate pain score and the amounts of drug requirement in each group were observed. Results The analgesia effect was good in 3 groups, no significant influence in body temperature （P〈0. 05）. The amounts of drug requirement were the most in group L in 0-24 hours （P〈0. 01, P〈0.05）. There was no difference between group L-M and group M （P〉0.05）. The side effects of nausea, vomiting and pruritus cutanea were the highest in group M （P〈0.05）. There was no difference between group L-M and group L （P〉0. 05）. Conclusion Aspirin-DL-Lysine combined Morphine used in postoperative peridural self control analgesia can both pledge a good effect and decrease the side effect obviously.