期刊文献+

多发性硬化患者血清尿酸水平测定的临床意义

下载PDF
导出
摘要 目的探讨多发性硬化患者血清尿酸的水平及其临床意义。方法采用放射免疫法对24例多发性硬化患者治疗前后进行了血清尿酸测定。结果多发性硬化患者血清尿酸水平均显著降低,与对照组比较有显著性差异,治疗后进入稳定期尿酸水平有所提高,与对照组比较无显著性差异。结论测定多发性硬化患者血清尿酸水平有助于了解病情,判断病情活动性,尿酸对多发性硬化有保护作用,值得进一步研究。
作者 冯东泽
出处 《医学信息(西安上半月)》 2005年第8期1006-1006,共1页 Medical Information
  • 相关文献

参考文献2

二级参考文献32

  • 1[1]Noseworthy JH, Lucchinetti C, Rodriguez M, et al. Multiple sclerosis. N Engl J Med, 2000, 343:938-952.
  • 2[2]Hooper DC, Bagasra O, Marini JC, et al. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite:implications for the treatment of multiple sclerosis. Proc Natl Acad Sci USA, 1997, 94:2528-2533.
  • 3[3]Hooper DC, Spitsin S, Kean RB, et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci USA, 1998, 95:675-680.
  • 4[4]Drulovic J, Dujmovic I, Stojsavljevic N, et al. Uric acid levels in sera from patients with multiple sclerosis. J Neurol, 2001, 248:121-126.
  • 5[5]Toncev G, Milicic B, Toncev S, et al. Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and bloodbrain harrier dvsfunction. Eur J Neurol, 2002, 9:221-226.
  • 6[7]Knapp CM, Constantinescu CS, Tan JH, et al. Serum uric acid levels in optic neuritis. Mult Scler, 2004, 10:278-280.
  • 7[8]Toncev G, Milicic B, Toncev S, et al. High-dose methylprednisolone therapy in multiple sclerosis increases serum uric acid levels. Clin Chem Lab Med, 2002, 40:505-508.
  • 8[9]Constantinescu CS, Freitag P, Kappos L. Increase in serum levels of uric acid, an endogenous antioxidant, under treatment with glatiramer acetate for multiple sclerosis. Mult Scler, 2000, 6:378-381.
  • 9[10]Galboiz Y, Miller A. Immunological indicators of disease activity and prognosis in multiple sclerosis. Curr Opin Neurol, 2002, 15:233-237.
  • 10[11]Spitsin S, Hooper DC, Leist T, et al. Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease. Mult Scler,2001, 7:313-319.

共引文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部