高血压病患者24小时平均脉压与靶器官损害的关系

Relationship between average 24-hour ambulatory pulse pressure and target organ damage in hyper- tension patients

目的探讨高血压病患者24小时平均脉压(ABPP)与靶器官损害的关系。方法把246例高血压病患者根据动态血压检测的结果分为ABPP≥60 mmHg和ABPP<60 mmHg两组,将两组的超声心动图、心电图、血肌酐、颅脑CT资料进行对比分析。结果与ABPP<60 mmHg组比较,ABPP≥60 mmHg组心肌肥厚、心脏收缩和/或舒张功能减退、心电图异常、肾功能损害、脑血管意外病例明显增多。结论高血压病患者中,随着脉压增大,增加了对心脏、大脑、肾脏等靶器官的损害, 进而造成心脑血管疾病发病率增高,因此在高血压治疗中积极控制脉压将有效减轻靶器官损害。

Objective To investigate the relationship between average 24-hour ambulatory pulse pressure and target organ damage in hypertension patients. Methods Two hundred forty-six patients with hypertension were enrolled into the following two groups by the mean values of average 24-hour ambulatory pulse pressure（ABPP）.≥60 mmHg（n= 112） and ABPP〈60 mmHg（n= 134）. The data of Echocardiography, Electrocardiogram, Scr and cerebral CT were compared. Results In the group with ABPP≥60 mmHg the EF and E/A were significantly decreased, AO ,LVEDd , IVSD,LVPWd and LVMI were increased, while electrocardiogram abnormality, renal function damage and cerebral function damage were increased compared with ABPP〈60 mmHg. Conclusion Active control pulse pressure is effective to abate target organ damage in the treatment hypertension.