摘要
目的通过对诊断为肺炎的患儿疾病过程中各时期(包括心力衰竭并发症)肿瘤坏死因子-α(TNF-α)水平的测定, 结合临床分析,探讨TNF-α在小儿肺炎及心衰并发症过程中的作用及意义。方法采集小儿肺炎75例,其中肺炎合并心力衰竭15例,用双抗体夹心ELISA法检测患儿血清中TNF-α水平;随机取70例健康儿童为对照组。结果小儿肺炎血清TNF-α较对照组明显升高,合并心力衰竭时升高更显。普通肺炎经治疗好转后,TNF-α水平和对照组之间无显著性差异;肺炎合并心衰经治疗好转后TNF-α水平下降,但仍高于正常水平,与对照组及普通肺炎经治疗好转后对比有显著性差异。结论在小儿肺炎病例中,通过测定TNF-α水平,可作为患儿心肺功能程度判定和疗效观察的一项重要指标,可早期监测并筛选出重症及可能死亡病例,早期干预,降低病死率。
OBJECTIVE The aim of the study was to explore the clinical significance of change of serum ot tumor necrosis factor （TNF-α）in children＇s pneumonia and pneumonia comlicating heart failure. METHODS To retrospectively analyse the clinical data of 75 children＇s pneumonia and pneumonia complicating heart failure, including 60 common pneumonia and 15 pneumonia complicating heart failure. The lever of serum TNF-α was measured by enzyme linked immunosorbent assay（ELISA）with double antibody sandwich before and after treating,and compared with 70 normal subjests （control group）. RESULTS The lever of serum TNF-ot was higher in children＇s pneumonia than that in control group, and very high in pneumonia complicating heart failure.There were no significant different （P〈0.001）between common pneumonia after treatment and normal subjects, the level of TNF-ot reduced in pneumonia complicating heart failure, and was still higher than the control group, there were significant difference in the common pneumonia, pneumonia complicating heart failure and control group. CONCLUSIONS To measured the change of the level of TNF-α can be used to monitor the patient＇s condition and prognosis.
出处
《中国初级卫生保健》
2005年第8期85-86,共2页
Chinese Primary Health Care
关键词
支气管肺炎
心力衰竭
肿瘤坏死因子-Α
bronchopneumonia, heart failure, α tumor necrosis factor （THF-α）
