摘要
目的:制备利巴韦林缓释片,对其释放机制进行考察。方法:建立高效液相色谱(HPLC)体外释放度测定法,以羟丙基甲基纤维素(HPMC)为主要辅料,制备亲水凝胶型骨架片,采用单因素试验筛选辅料种类,通过均匀设计优化出缓释片的处方。结果:所制备的缓释片在8h内呈良好的零级释药特征。结论:以均匀设计优选的利巴韦林缓释片处方合理,体外释放性能良好。
OBJECTIVE To prepare ribavirin sustained release tablets and investigate its release mechanism in vitro. METHODS To establish a HPLC method for determing the content of ribavirin. The water-soluble matrix tablet was preparaed by use of HPMC.The optimal formulation was obtained by uniform design. RESULTS The release profile of the tablets in vitro was fitted well by zeros-order release within 8 hours. CONCLUSION The formulation and the release mechanism in vitro is reasonable.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2005年第7期628-631,共4页
Chinese Journal of Hospital Pharmacy
关键词
利巴韦林
缓释片
释放度
均匀设计
ribavirin
sustained release tablet
drug release
uniform design
