马蔺子素配合放疗对鼻咽癌颈部淋巴结转移灶的近期疗效观察

Effect of Combined Irisquinone and Radiotherapy on cervical Lymph Nodes Metastasised From Nasopharyngeal Cancer

目的观察马蔺子素合并放射治疗对鼻咽癌颈部淋巴结转移灶的疗效。方法采用马蔺子素合并放疗(研究组)与单纯放疗(对照组)疗效对照。结果研究组鼻咽癌颈部淋巴结全消率为71.7%(43/60),明显高于对照组的51.9%。毒性反应主要为消化道症状,而皮肤反应及口咽反应两组无显著差异,不良反应可耐受。结论马蔺子素的增敏作用主要针对肿瘤本身,而对口咽黏膜及皮肤没有明显的增敏作用,不会增加其放射损伤,是一种比较有效且低毒的新型放射增敏剂。

Objective To evaluate the radiosensitizing effect of Irisquinone combined with radiotherapy for cervical lymph nodes metastasised From nasopharyngeal cancer. Methods Out-irradiation of 60Co-r including cervical metastatic lymph nodes DT 60-70Gy were used. Irisquinone 110mg tid orally was given one day prior to the radiotherapy and it was continued until the end of irradiation. Results In the treatment group, the CR of metastatic cervical nodes were 71.7%, while in the control group, CR of metastatic cervical nodes were 51.9% respectively. In comparison , the CR of the treatment group were higher than those in the control group. Conclusion The result showed that Irisqinone has significant radiosensitizing effects on cervical lymph nodes metastasised from nasopharyngeal cancer.