缩醛法合成1,1-二甲氧基丙酮

Synthesis of 1,1-dimethoxy-2-propanone by acetalation

1,1-二甲氧基丙酮是一种重要有机中间体,本文采用缩醛化反应,以丙酮醛为原料,与甲醇在浓硫酸催化作用下合成1,1-二甲氧基丙酮,反应较佳条件为浓硫酸:丙酮醛:甲醇=0.03:1:7(摩尔比),反应温度为65℃。

1,1-dimethoxy-2-propanone is an important intermediate in fine chemistry. It was synthesized from pyruvaldehyde and methanol by sulfuric acid catalyst. The results showed that the optimum conditions are as follows： sulfuric acid： pyruvaldehyde： methanol, 0.03：1：7（mol）; reaction temperature 65^oC.