头颈部恶性淋巴瘤

A Clinical Analysis for Malignant Lymphoma in Maxilloface and Neck

目的:探讨颌面颈部恶性淋巴瘤(ML)的诊断方法与治疗措施。方法:回顾分析1991年10月至2000年10月收治的ML患者68例,其中男42例,女26例;年龄11岁～67岁,中位年龄为46岁。霍奇金病(HD)5例,非霍奇金淋巴瘤(NHL)63例。41例患者采用综合治疗,27例采用单纯化疗或放疗。结果:68例患者的1a、3a、5a生存率分别为44.12%、19.12%和13.23%,存活患者中以临床I期、期者占绝大多数,死亡患者以期、期为多。结论:颌面颈部ML发病率有增长趋势;对颈部原因不明的淋巴结肿大应反复活检以明确诊断;综合治疗最为有效的治疗手段;临床分期对预后有重要参考价值。

Objective To investigate the diagnosis and treatment of malignant lymphoma （ML） in maxilloface and neck. Methods From October of 1991 to October of 2000,68 patients（42 male and 26 female）with ML in maxilloface and neck admitted in our department. 5 cases were Hodgkin＇s disease（HD）and 63 cases non-Hosgkin＇s lymphoma（NHL） ,41cases accepted systemic treatment ,27 cases chemotherapy or radiotherapy only. Results The survial rate of 1.3 and 5 years for 68 patients was 44, 12%, 19. 12% and 13. 23%, Among survivals;most were Ⅰ and Ⅱ stage clinically, while in those dead patients, most belonged to Ⅲ and Ⅳ stage. Conclusions There was an significantly increasing trend for incidence of ML in maxilloface and neck and repeated biopsy should be carried out if unclear mass in these regions. Chemotherapy combined with radiotherapy and operation is still the effective therapeutic means. The clinical staging classification is worth the prognosis.