胃安泰胶囊对胃癌前期病变大鼠胃壁微循环的影响

Influence of Weiantai Capsule on the Micro-circulation in Gastric Folds of Rats with Precancerous Lesion of Gastric Cancer

目的:研究中药复方胃安泰胶囊对PLGC大鼠胃壁微循环的影响,探讨胃安泰胶囊对PLGC的防治作用及作用机制。方法:采用综合造模方法建立PLGC的大鼠模型。造模以前,将实验大鼠随机分为正常组、预防组、造模组。预防组大鼠在造模的同时灌服胃安泰胶囊,最后和其他各组进行比较。确认造模成功后,将参与造模的大鼠随机分为高剂量胃安泰给药组、中剂量胃安泰给药组、低剂量胃安泰给药组、维酶素给药组和病理对照组,分别进行灌胃。实验结束后摘取胃,测定胃壁血液的流速、浓度、流量,探讨胃安泰胶囊对胃癌前期病变大鼠胃壁微循环的影响。结果:胃安泰胶囊能够改善胃癌前期病变大鼠胃壁微循环。结论:胃安泰胶囊对胃癌前期病变有很好的预防和逆转作用。

Objective： Tostudy the influence of Compound Weiantai Capsule on the micro-circulationin gastric folds of rats with precancerous lesion of gastric caneer （PLGC） and probe the mechanism ofaction of preventing and treating PLGC by Weiantai Capsule. Methods： Model rats with PLGC were made with the comprehensive modelling method. before the modelling, the rats were randomly divided into the Nomal Group, the Preventing Group and the Modelled Group. The Preventing Group were give Weiantai Capsule at the same time of modelling, and then compared with other groups. After the successful modelling, the modelled rats were randomly divided into the high-dosed ,medium-dosed and low-dosed Weiantai Capsule groups, Vitacoenzyme Group and Pathological Controlled Group. After the experiment, the stomaches were excised to examine the flow rate and potency of blood in gastric folds and probe the influence of Weiantai Capsule on the micro-circulation in gastic foles of rats with precancerous lesion of gastric cancer .Result： Weiantai Capsule can improve the micro-circulation in gastric folds of rats with precancerous lesion of gastric cancer. Conclusion： Weiantai Capsule has a great preventing and inversion function to PLGC.