咪康唑和益康唑的PEG-400连续催化N-和O-烷基化反应制备

Preparation of Miconazole and Econazole by PEG-400 Catalyzed Reactions of Tandem N- and O-Alkylation

用氢氧化钠作碱,PEG-400为相转移催化剂,在THF中不经分离连续完成1-(2,4-二氯苯基)-2-氯乙醇的N-和O-烷基化反应,制得抗真菌剂硝酸咪康唑和硝酸益康唑,收率分别为63%和68%。

In presence of NaOH, using PEG-400 as phase transfer catalyst, tandem reactions of N- and O-alkylation of 1- （2,4-dichlorophenyl） -2-chloroethanol were performed in THF to afford miconazole and econazole with yields of 63 % and 68 %, respectively.