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西他沙星合成路线图解 被引量：3

Graphical Synthetic Routes of Sitafloxacin
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作者 金卫东 周伟澄
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第8期515-518,共4页 Chinese Journal of Pharmaceuticals
基金 上海市科委资助项目(04DZ05902 04JC14068)
关键词 合成路线图解 2001年11月 氟喹诺酮类 制药公司 起始原料 化学名 环丙基 抗菌剂 水合物
分类号 TQ464.7 [化学工程—制药化工] S859.796 [农业科学—临床兽医学]
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参考文献8

  • 1Yukimoto J, Ehata T, Tojo T, et al. Preparation of 2-fluorocyclopropanemethanol and 2-fluorocyclopropanecarboxylic acid[P]. JP: 07109237, 1995-04-25. (CA 1995, 123:313432)
  • 2Hayakawa I, Kimura Y. Optically active pyridonecarboxylic acid derivatives [P]. EP: 0341493, 1989-11-15. (CA 1990, 113:40473)
  • 3Kanbara S, Ehata T, Shimizu S. Preparation of fluorocyclopropylamines as intermediates for a bactericide [P]. JP:07048338, 1995-02-21. (CA 1995, 123: 169277)
  • 4Tamura O, Hashimoto M, Kobayashi Y, et al. Synthesis and optical resolution of dl-cis-2-fluorocyclopropylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859 [J]. Tetrahedron Lett, 1992, 33: 3483-3486.
  • 5Tamura O, Hashimoto M, Kobayashi Y, et al. Asymmetric synthesis of (1R,2S)-2-fluorocyclopropylamine, the key intermediate of the new generation of quinolonecarboxylic acid, DU-6859 [J]. Tetrahedron Lett, 1992, 33: 3487-3490.
  • 6Kimura Y, Atarashi S, Kawakami K, et al. (Fluorocyclopropyl) quinolones 2. Synthesis and stereochemical structure-activity relationships of chiral 7- (7-anmino-5-azaspiro [2,4] heptan-5-yl) -1- (2-fluoro-cyclopropyl) quinolone antibacterial agents[J]. J Med Chem, 1994, 37: 3344-3352.
  • 7Imura A, Myadera A. Manufacture of high-purity optically active spiro compounds with phaeocreopsis species [P]. JP:08157454, 1996-06-18. (CA 1996, 125: 193596)
  • 8Yukimoto Y, Kaneuchi T, Kimura Y. Process for preparing 8-chloroquinolone derivatives [P]. CN: 1062906, 1992-07-22. (CA 1993, 119: 117137)

同被引文献16

  • 1周伟澄,周后元.氟喹诺酮类抗菌药物研究进展[J].中国医药工业杂志,2005,36(5):309-312. 被引量：18
  • 2陈超森,曾卓,熊淑群.喹诺酮类药物的研究进展[J].精细化工中间体,2005,35(5):1-5. 被引量：15
  • 3詹国青,周多刚,陈乐文.N-(2-羟乙基)-邻苯二甲酰亚胺的合成研究[J].浙江化工,2007,38(10):4-5. 被引量：1
  • 4Sato K,Hoshino K,Tanaka M,et al.Antimicrobial activity of DU-6859,a new potent fluoroquinolone,against clinical isolates[J].Antimicrob Agents Chemother,1992,36(7):1491-1498.
  • 5Onodera,Y.A low est risk of sitafloxacin-resistant mutants[J].A ntimicrob A gents Chemother,1999,44(4):533.
  • 6Nakajima R,Kitamura A,Someya K,et al.In vitro and in vivo antifungal activities of DU-6859a,a fluoro-quinolone,in combination with amphotericin B and fluconazole against pathogenic fungi[J].Antimicrob Agents Chemother,1995,39(7):1517-1521.
  • 7行本裕介,金内彻,木村阳一,等.8-氯代喹诺酮衍生物的制备方法:CN,1062906[P].1992-10-18.
  • 8Okumura R,Hirata T,Onodera Y. Dual-targeting properties of the 3-aminopyrrolidyl quinolones,DC-159a and sitafloxacin,against DNA gyrase and topoisomerase Ⅳ:contribution to reducing in vitro emergence of quinoloneresistant Streptococcus pneumonia[J].{H}Journal of Antimicrobial Chemotherapy,2008,(1):98-104.
  • 9Sato K,Hoshino K,Tanaka M. Antimicrobial activity of DU-6859,a new potent fluoroquinolone,against clinical isolates[J].{H}Antimicrobial Agents and Chemotherapy,1992,(7):1491-1498.
  • 10Nakajima R,Kitamura A,Someya K. In vitro and in vivo antifungal activities of DU-6859a,a fluoro-quinolone,in combination with amphotericin B and fluconazole against pathogenic fungi[J].{H}Antimicrobial Agents and Chemotherapy,1995,(7):1517-1521.

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二级引证文献4

中国医药工业杂志
2005年 第8期

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