摘要
目的研究腺病毒介导的人重组骨形成蛋白-2(ad-hBMP-2)对兔下颌骨骨折愈合的影响。方法16只新西兰白兔随机分成实验组和对照组各8只,建立一侧下颌骨骨折模型后3d,在两组实验动物骨折处注射100μl的ad-hBMP-2病毒液和生理盐水,注射术后4周切取标本,进行X线观察和组织学检查。结果实验组动物骨折处新骨形成量及骨小梁密度显著优于对照组(P<0.05)。结论ad-hBMP-2可明显促进兔下颌骨骨折愈合。
Objective： To study the effect of bone morphogenetic proteins-2 （ad-hBMP-2） gene therapy on mandibular fracture union. Methods： An animal model of mandibular fracture was established in 16 rabbits which were divided randomly into experimental and control group. 100μl ad-hBMP-2 and normal saline were injected respectively into the breaking end of fracture 3 days after operation. All animals were killed 4 weeks after operation and the samples were examined by X-ray and histology. Results： The rate of the new bone formation and the density of the rebirth bone trabecula of the experimental group were superior to the control. Conclusion：ad-hBMP-2 gene therapy can accelerate bone formation during mandibular fracture in rabbits.
出处
《山东医药》
CAS
北大核心
2005年第21期11-12,共2页
Shandong Medical Journal
基金
国家自然科学基金资助项目(30471796)
关键词
骨形成蛋白-2
基因治疗
骨折
hone morphogenetic proteins-2
gene therapy
fracture
