摘要
目的了解奎硫平与氯氮平治疗精神分裂症的疗效和不良反应差异。方法应用Meta分析对14项研究奎硫平与氯氮平治疗精神分裂症对照研究的文章进行再分析,评价其合并效应量的大小和综合显著性检验。结果①奎硫平治疗前后的自身对照,合并效应量d=3.74,95%CI(0.188,7.29),综合显著性检验(χ2=7.80,P<0.01),提示奎硫平治疗精神分裂症前后症状学变化有非常显著性差异,效应极强。②奎硫平与氯氮平的组间比较,d=-0.108,95%CI(-0.680,0.465),综合显著性检验(χ2=0.136,P>0.8),提示这两种药物的疗效没有显著性差异,差异效应弱。③奎硫平组的低血压不良反应比氯氮平组多,但差异无显著性(χ2=2.77,P>0.05),其它的11种不良反应均比氯氮平组少,除了锥体外系不良反应(EPS)没有显著性差异外(χ2=0.720,P>0.05),其它均达到显著性差异(χ2=16.7-178),其发生的比值比(OR)合并效应在1.27～10.6倍之间。结论虽然奎硫平与氯氮平在平均8周左右的疗效无显著性差异,但不良反应却有显著不同。
Objective To study the difference in theapeutic effects and side effects between quetiapine and clozapine. Methods 14 studies that compare effects differences in treated schizophrenia was analysed by meta-ana]ysis in tbeapeutic effects and side effects. Result The significant difference in change of symptom before and after treatment by quetiapine was found ,d = 3.74,95% CI（0. 188,7.29） ,X^2 = 7.80 ,P 〈 0. 01;No significant difference in change of negative symptom between treatment by quetlapine group and clozapine group,d = -0. 108,95%CI（ -0. 680,0. 465） ,X^2=0. 136,P 〉 0. 8;The incidence of hypertension in quetlapine group was different form clozapine group, but no significant different,the othe side effects were lower in quetiapine group that clozapine group（X^2= 16. 7 - 178） ,expect for EPS（X^2=0.72,P 〉0. 05 ）. Their odd ratio（OR） were found fron 1.27 to 10. 6. Conduslon Quetiapine difference from clozapine is in side effects,but not in therapeutic effects.
出处
《四川精神卫生》
2005年第3期142-146,共5页
Sichuan Mental Health
