细胞凋亡与子宫内膜异位症研究进展

Progress in research on relationship between apoptosis of endometrial cells and endometriosis

越来越多的证据表明,子宫内膜异位症患者与正常人子宫内膜存在许多不同之处,表现为内异症患者的子宫内膜细胞粘附、侵袭和血管形成能力明显增强,使之具有异位种植和生长的能力,在内异症的发生和发展中起重要作用。最近研究表明,子宫内膜细胞自发性凋亡减弱和对凋亡信号不敏感,可能是内膜细胞具有异位种植和生长能力的重要因素。现就细胞凋亡在正常子宫内膜周期变化中的作用,以及对子宫内膜异位症发生发展的影响作以综述。

Accumulating evidences suggest that endometrial cells of women with endometriosis are different from those of normal women, Endometrial cells of women with endomc triosis have enhanced proliferation and increased ability to implant and survive in ectopiclocations. Recent study indicated that impaired sensitivity of endometrial tissue to death signal and decreased spontaneous apoptosis may be two important factors and contribute to the abnormal implantation and growth of endometrium at ectopic sites, resulting in development of endometriosis. In this paper, we reviewed role of apoptosis in periodic changes of normal endometrium and its infinenccs on occurrence and development of endometriosis.