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阿司匹林对急性冠脉综合征中C-反应蛋白的影响及其意义 被引量:1

The effect of aspirin oil C-reactive protein and short prognosis in acute coronary syndrome
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摘要 目的观察入院前服用阿司匹林(ASP)对非ST段抬高的急性冠脉综合征(ACS)患者C反应蛋白(CRP)及住院期间预后的影响。方法146例非ST段抬高的ACS患者,入院次日采用免疫比浊法测定CRP,正常值为0.1~5.2mg/L。超过正常值为阳性,在正常值范围内为阴性。观察终点:心性死亡、非Q波心肌梗死(NQMI),顽固性心绞痛(RA)。结果服ASP46例(A组),未服96例(B组)。住院期间共发生NQMI26例,RA40例,无1例死亡。发现:①CRP阳性率A组低于B组(44%∶68%,P<0.01)。②NQMI、RA发生率A组低于B组(8.3%∶22.4%,P<0.05;14.3%∶33.7%,P<0.05)。③CRP阳性者NQMI、RA发生率均高于CRP阴性者(23.3%∶10.0%,P<0.05;34.9%∶16.7%,P<0.05)。④CRP均阳性时,二组间NQMI、RA发生率无差异(14.3%∶26.2%,P>0.05;23.8%∶38.5%,P>0.05)。结论CRP阳性率与非ST段抬高性ACS患者住院期间心脏事件呈正相关。ASP可降低CRP阳性率,并降低心脏事件发生率,但对CRP阳性者的近期预后影响不大。 Objective To assess the effect of aspirin on c-reactive protein(CRP) and clinical manifestarmg of patients with non-ST-elevation acute coronary syndrome(ACS) during hospitalization. Methods We assessed 146 patients admitted whth non-ST-elevation ACS. Serum CRP concentration were measured by immunonephelometry at second day after admission. CRP concentration ranging from 0. 1 to 5.2mg/L. It was positive and negative when CRP concentration was high and equal to the ranging. End point was cardiac death, non-Q-wave myocardial infarction ( NQMI ) and refractory angina ( RA ). Results A total of 46 patients ( group A) were taking and 96 patients( group B)were not taking aspirin before admission. Rate of positive CRP was lower in group A than in group B(44% :68% ,P 〈0. 01) ; Morbidity of NQMI and RA were all lower in group A than in group B((8.3%: 22. 4%,P〈0.05;14.3%: 33.7%,P〈0. 05) ;Mobidity of NQMI and RA were all higher in patients with positive CRP than in patients with negative CRP(23.3%: 10. 0% ,P 〈0.05 ;34. 9% : 16. 7% ,P 〈0. 05 ) ;Difference of morbidity in NQMI and RA were not significant when CRP was all positive in two groups(14.3%: 26.2% ,P〉0.05;23.8%: 38.5% ,P〉0.05). Conclusion Increased concentration of CRP was correlated positively with cardiac events in patients with ACS during hospitalization. Aspirin can reduce CRP concentration and morbidity of cardial events. But the effect of aspirin on patients with positive CRP was not significant.
出处 《滨州医学院学报》 2005年第4期249-250,共2页 Journal of Binzhou Medical University
关键词 阿司匹林 C-反应蛋白 急性冠脉综合征 aspirin, C-reactive protein, acute corronary syndrome
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  • 1Kennon S,Price CP,Mills PG,et al.The effect of aspirin on C-reactive protein as marker of risk in unstable angina[J].J Am Coll Cardiol,2001,37:1266
  • 2Yeh EYH,Anderson HV,Pascer V,et al.C-reactive protein LingRing inflammation to cardiovascular complications[J].Circulation,2001,104:974
  • 3Koenig W,Sun M,Frohlich M,et al.C-reactive protien,a sensitivity marker of inflammation[J].Circulation,1999,99:237
  • 4魏有仁.C反应蛋白方法学与应用的进展[J].当代医学,2001,10:27-27.
  • 5Kennon S,Suliman A,MacCallum PK,et al.Clincal characteristics determining the mode of presentation in patients with acute coronary syndromes[J].J Am Coll Cardiol,1998,32:2018
  • 6Garcia-Doredo D,Therous P,Tornos P,et al.Previous aspirin use may attenuate the severity of the manifestation of acute ischemic syndrome[J].Circulation,1995,92:1743
  • 7Rebuzzi AG,Quaranta G,Liuzzo G,et al.Incremental prognosis of serum levels of troponin T and C-reactive protein on admission in patients with unstable angina[J].Am J Cardiol,1998,82:715
  • 8Dewinter RJ,Bholasingh R,Lijmer JG,et al.Independent prognostic value of C-reactive protein and troponin I in patients with unstable angina or non-q-wave myocardiol infarction[J].Cardiovasc Res,1999,42:240
  • 9Morrow DA,Rifai N,Antman E,et al.C-reactive protein is a potent predictor of mortality independently of and in Combination with troponin T in acute coronany syndromes:a TIMI 11 A Sub-study[J].J Am Coll Cardiol,1998,31:1460

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