N-苯基马来酰亚胺最佳合成工艺条件的研究

Research into the optimum technical condition of N-Phenyl Maleimide

目的研究N-苯基马来酰亚胺合成新工艺。方法以乙酸乙酯作溶剂、醋酐作脱水剂、醋酸钠作催化剂合成N-苯基马来酰亚胺,采用正交实验方法确定最佳工艺条件。结果脱水剂用量为15ml、催化剂为20mmol、反应温度为55℃、反应时间为60min时N-苯基马来酰亚胺的收率可达89%。结论产品经晶形、熔点和红外光谱分析确定为目标产品。

Objective： To establish a new synthesis technology of N-Phenyl Maleimide. Methods： N-Phenyl Maleimide was synthesized by the use o{ ethyl acetate as solvent, acetic anhydride as dehydrating agent and sodium acetate as catalyst. The optimum technical conditions were researched by orthogonal tests, Results： The optimum conditions were achieved with the amount of dehydrating agent, 15ml; the amount of catalyst, 20mmol; the reaction temperature, 55℃ ;the reaction time, 60min. The yield of N-Phenyl Maleimide was 89%. Conclusion： The product is identified by crystal form, melting point and IR test.