冠脉造影无明显狭窄患者斑块面积大小对血管重构的影响

The effect of plaque area on vascular remodeling of vessel in the patients with angiographically insignificant stenosis

目的用血管内超声(IVUS)探讨冠脉造影无明显狭窄患者的冠状动脉斑块面积大小对血管重构的影响。方法临床拟诊冠心病(CAD)者,经冠脉造影(CAG)发现无明显狭窄(直径狭窄率<50%)者22例行IVUS检查,根据CAG结果对罪犯血管行IVUS检查。分别分析血管面积与斑块面积之间、管腔面积与斑块面积之间的相关性。结果(1)血管面积随斑块面积的增加而增加,成线性相关;(2)当斑块面积<50%时,管腔面积与斑块面积成线性正相关(r=0.47,P<0.01)。当斑块面积≥50%时,管腔面积与斑块大小不相关(r=0.43,P<0.05)。结论冠脉造影无明显狭窄患者,冠状动脉血管面积、管腔面积与斑块面积存在一定相关性。斑块面积大小对血管重构具有一定的影响。

Objective To investigate the effect of coronary plaque area on vascular remodeling.Methods Intravascular ultrasound （IVUS）was performed in 22 patients with angiographically insignificant stenosis （the diameter of stenosis 〈 50% ）. The vessel area,lumen area and plaque area were measured,and the relation between vessel area and plaque size was analyzed, the relation between lumen area and plaque size were analyzed by linear regression respectively. Results The vessel area increased with the increasing of the plaque area and showed linear regression, If the plaque area stenosis percentage is less than 50%, the lumen area shows positive linear regression with the plaque area, （ r = 0.47, P 〈 0,01 ） ,when the plaque area stenosis was not less than 50%, this relation disappeared （ r = 0.43, P = 0.052）. Conclusion There is a relationship among the external elastic membrane area, lumen area and plaque size, Plaque area has effect on vascular remodeling of patients with angiographically insignificant stenosis.