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缺血性脑梗死患者D-二聚体定量检测的临床研究

Clinical study of quantitative detection of D-dime in plasma of patients with cerebral ischemic infarction
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摘要 目的:了解缺血性脑梗死患者在不同阶段血浆D-二聚体测定的意义.方法:随机选择42例到本院神经内科就诊的缺血性脑梗死患者(年龄53~90岁,男21例,女21例),分别于急性期(<6天,n=27,年龄53~87岁)和亚急性期(6~20天,n=15,年龄51~90岁)行血浆D-二聚体测定.患者均经头颅CT证实为缺血性脑梗死.同时选择年龄相匹配的20例其他非凝血及血栓性疾病患者(年龄61~87岁)作为对照组.结果:缺血性脑梗死患者的血浆D-二聚体水平在急性期未见升高(<0.5 mg/L),而在亚急性期显著升高(≥0.5 mg/L,0.5~2 mg/L),亚急性期与对照组(<0.5mg/L)比较差异有显著性(P<0.001),与急性期比较差异也有显著性(P<0.001)(正常值为<0.5mg/L).结论:缺血性脑梗死患者的纤溶系统显著激活并非在急性期,而是在亚急性期.这也为急性期进行溶栓治疗提供了依据. Objective: The purpose of this study was to clarify differences in fibrinolytic activation among the various phases of cerebral ischemic infarction.Methods:D - dimer were measured in 42 patients with cerebral ischemic infarction(51 ~ 90 years, men 21, female 21) and 20 age - matched controls. All 42 patients were divided into two groups, 27 cases were during acute phases( 〈 6 days) and 15 cases were during subacute phases ( 6 ~ 20 days ). Results: The levels of D - dimer were significantly higher ( ≥ 0.5 mg/L, 0.5 - 2 mg/L) during subacute phases of cerebral ischemic infarction than those in the controls ( 〈 0.5 mg/L, P 〈 0. 0001), however, the levels of D - dimer were not elevated ( 〈 0.5mg/L)during the acute phases of cerebral ischemic infarction (normal was 〈 0.5 rag/L), which were less than those during subacute phases( P〈 0.0001) .Conclusion: Our findings suggested that fibrinolytie activations were significantly increased during subacute phases of cerebral ischemic infarction, and were not increased during acute phase.
出处 《现代医药卫生》 2005年第15期1939-1939,共1页 Journal of Modern Medicine & Health
关键词 缺血性脑梗死 D-二聚体 纤溶 D-dimer Cerebral ischemic infarction Fibrinolytic activation
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参考文献4

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