介入性化疗治疗宫颈癌的临床分析

Clinical analysis of interventional chemotherapy for cervical cancer

目的:探讨宫颈癌治疗中介入性化疗的临床疗效、病理学变化。方法:对32例宫颈癌患者进行随机分组,分别给予介入性化疗和全身静脉化疗,抗癌药物选择表阿霉素、卡铂或顺铂。结果:32例宫颈癌中介入组9例(9/16)经病理学检查提示化疗有效,其中组织学完全缓解(HCR)3例;两种方法对宫颈癌的治疗均有效,但其疗效有差别,介入组的疗效优于静脉组。结论:介入化疗可有效提高宫颈癌组织内的抗癌药物浓度,缩小肿瘤体积,部分患者达到HCR的效果。

Objective： To evaluate the therapeutic effect and pathological changes in patients with cervical cancer after interventional chemotherapy.Methods： Thirty- two cases of cervical cancer who were divided into two groups at random were performed chemotherapy by interventional and intravenous methods with epirtrbicin,carboplatin or cisplatin respectively.Results：Among thirty- two patients,nine cases（9/16） of interventional chemotherapy were proved to be effective by the diagnosis. Three cases were noted histological complete recovery （HCR） clinically. Two methods were all effective to treat cervical cancer, but their effects were different.The effect of interventional chemotherapy was higher than that of intravenous chemotherapy. Conclusion： The interventional chemotherapy is proved to be effective in increasing the concentration of drugs in tumor tissue as well as in reducing tumor size. Some patients can reach HCR.