小剂量氯胺酮复合丙泊酚用于无痛人流的临床观察

Small dose of ketamine combined with propofol for painless artifical aborti on

目的:探讨小剂量氯胺酮复合丙泊酚在无痛人流应用中的有效性及安全性.方法:40例ASA分级Ⅰ～Ⅱ择期要求无痛人流的病人,随机分成两组各20例,Ⅰ组丙泊酚3 mg/kg,Ⅱ组氯胺酮0.4 mg/kg加丙泊酚2 mg/kg,术中视病人反应和手术时间追加丙泊酚30～50mg,观察手术过程中血压(BP)、心率(HR)、动脉血氧饱和度(SpO2)、呼吸、苏醒时间等指标.结果:所有患者诱导后BP、HR均下降,Ⅰ组较Ⅱ组下降更明显,差异有显著性(P＜0.05).Ⅰ组丙泊酚用量明显大于Ⅱ组(P＜0.01),苏醒时间两组间差异无显著性(P＞0.05).结论:小剂量氯胺酮复合丙泊酚是无痛人流手术安全有效的麻醉方式.

Objective： To explore the effectiveness and safety of use of small dose of ketamine combined with propofol in the operation of painless artifical abortion.Methods： Forty ASA Ⅰ～Ⅱ patients were randomly divided into two groups. Group Ⅰ （n = 20） was given propofol 3mg/kg group Ⅱ （n = 20） was given ketamine 0.4 mg/kg intravenousty added with propofol 2 mg/kg intravenously. Adding propofol 30～ 50mg if there was demand in the operation.BP, HR, SpO2, RR, wake up time ete.were observed during the operation.Results： After induction on all patients,BP,HR went down,and there were more significantly down in group Ⅰ than in group Ⅱ （P 〈 0.05）.The total dosage of propofol in group Ⅰ was significantly larger than that in group Ⅱ （ P 〈 0.01） . The recovery time had no significan difference between two groups（ P 〉 0.05）. Conclusion： Small dose of ketamine combined with propofol in painless artifical abortion is an effective and safe method.