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G蛋白偶联受体研究进展 被引量：2

Research Development of G Protein-coupled Receptors
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摘要 G蛋白偶联受体(GPCRs)是体内最大的蛋白质超家族,根据结构的同源性,主要分为A、B、C3族.GPCRs配体的多样性决定配体结合域的多样性.受体分子内相互作用力的破坏、质子化、构象改变、与G蛋白的偶联及受体二聚化参与了GPCRs的活化过程,近年发现GPCRs的失敏和内吞对受体功能调节亦非常重要,本文拟综述以上内容的研究进展. G Protein- coupled Receptors（GPCRs） are maximal protein - superfamily in body which composed of A, B and C three family on the basis homdogy of the construction. Multiplicity of GPCRs ligand decide on Multiphcity of hgand combine - field. They are concemced with activation process of GPCRs that are destory of interactional force in receptor, protonate, conformation be changed, coupled with G protein or receptor dimerization. Recently, desensitization and hgand of GPCRs play an important role in adjust of recepeor function. Progress in the study of these content are reviewed in this paper.
作者 潘国庆
机构地区 青海民族学院化学系
出处 《青海师范大学学报（自然科学版）》 2005年第3期57-61,共5页 Journal of Qinghai Normal University(Natural Science Edition)
关键词 G蛋白偶联受体 双聚化 失敏及内吞 信号传导 G Protein - coupled Receptors dimerization desensitization and internalization signal transmit
分类号 Q51 [生物学—生物化学]
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参考文献13

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共引文献2

同被引文献23

  • 1郭志云,张怀渝,梁龙.G蛋白偶联受体的结构与功能[J].生命的化学,2004,24(5):412-414. 被引量：13
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引证文献2

二级引证文献4

青海师范大学学报（自然科学版）
2005年 第3期

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