维生素E添加治疗儿童难治性癫痫的实验研究

The clinical trial of vitamin E as a add-on therapy for children with intractable epilepsy

目的:为研究抗氧化剂维生素E在儿童难治性癫痫中的治疗作用,将维生素E作为添加剂治疗了35例儿童难治性癫痫患者。方法:实验分两步进行,先行3个月抗癫痫药(AED)基础治疗,然后加用维生素E治疗3个月,观察痫性发作频率的变化,同时检测血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、谷胱甘肽(GSH)、脂质过氧化物(LPO)的变化。结果:基础治疗期间痫性发作频率为16.29±7.16与维生素E添加治疗期间10.06±3.86相比差异有显著意义(P<0.001),添加维生素E后SOD、GSH-PX均有回升,LPO有所下降,与添加前比较差异有显著性,但GSH变化不大,在研究过程中未见明显不良反应发生。结论:维生素E添加治疗儿童难治性癫痫有效且安全,其机理可能与自由基参与癫痫的发病过程有关,也可能与维生素E的细胞保护作用有关。

Objective： This project is a research study to see if vitamin E helps children with epilepsy have fewer seizures, vitamin E was used as add-on therapy in 3 5 children with intractable epilepsy. Methods： The study consisted of a 3-month baseline period followed by a 3-month treatment phase with vitamin E as add-on therapy, the change in the seizure frequency was recorded, and the serum contents of SOD, GSH-PX, GSH, LPO were investigated. Results： The results indicated mean seizure frequency in the baseline period was 16.29＋_ 7.16 as compared with 10. 06 i 3.86 during add-on therapy phase, significant change in seizure frequency was observed with vitamin E as compared with baseline treatment（P〈0. 001）, the contents of serum SOD,GSH-PX in the vitamin E treatment periods were remarkably increased as compared with baseline periods（P〈0.01 ）, and the content of LPO was significantly decreased（P〈0.01 ）, no significantly side effects were noted during the study. Conclusion The authors considered that vitamin E as a add-on therapy in intractable epilepsy in children is effective and safety.