倍他乐克对慢性充血性心力衰竭患者心率变异性的影响

Effects OF Betaloc on Heart Rate Variability in Chronic Congestive Heart Failure

目的探讨倍他乐克对慢性充血性心力衰竭患者自主神经功能的影响。方法符合该研究入选标准的慢性心力衰竭患者50例,随机分成常规治疗组为对照组(n=21),常规治疗基础上加用倍他乐克者为治疗组(n=29),从小剂量开始,缓慢增加剂量,于第4周末行24小时动态心电图检查,比较两组心功能和HRV各项时域指标。结果治疗1月后,治疗组和对照组间HRV的SDNN、SDANN、PNN50、rMSSD均有显著性差异(P<0.05),且心功能改善,生活质量提高,随访半年,治疗组的再住院率、死亡率均少于对照组(P<0.05)。结论在常规治疗的基础上,加用倍他乐克治疗慢性充血性心力衰竭,提高HRV,增强疗效,改善预后。

Objective To study the effects of the betaloc on HRV （heart rate variability） of chronic congestive heart failure （CHF）. Methods A total of 50 case of CHF were classified as the treatment group （n= 29） with betaloc and normal treatment group （n=21）. Began with the minimum dosage, and then increased the dosage gradually. Hoher tape was performed in 50 patients at the end of the fouth week. After 1 mouth of treatment, analyzed parameters of HRV before and after treatment. Results HRV parameters of the betaloc treatment group were higher than those of the normal treatment group. There was significant difference （P〈0.05） in SDNN, SDANN, rMSSD and PNN50. The cardiac function and quality of life got improved. Furthermore the rate of motility and re-hospitalization were less than those of the normal treatment group after 6 mouth of observation. Conclusions Based on the traditional therapy, taking Betaloc additionally to treat chronic congestive heart failure can increase the HRV,enforce the treatment effect and improve the situation.