P73α在乳腺癌中的表达及其意义

Expression and clinical significance of p73α in breast carcinoma tissues

目的:研究p73α在乳腺癌组织中的表达及与乳腺癌临床病理特征的关系及其临床意义。方法:应用免疫组织化学方法检测41例乳腺癌组织,13例乳腺纤维腺瘤组织和8例正常乳腺组织中p73α、p53、p21的表达情况。结果:41例乳腺癌组织中有20例(48.8%)p73α呈阳性表达,阳性检出率显著高于乳腺纤维腺瘤组织(7.7%)和正常乳腺组织(0)(P<0.05)。41例乳腺癌组织中p53蛋白阳性表达的有20例(48.8%),p21蛋白阳性表达有32例(78.0%);乳腺癌中p73α的阳性表达与p53蛋白的表达具有正相关关系(P<0.05),而与p21蛋白的表达无明显相关(P>0.05)。乳腺癌中p73α的阳性表达与TNM分期、淋巴结转移有明显关系(P<0.05)。结论:p73α在乳腺癌中表达水平上调,p73α的表达上调可能与乳腺癌的发生、发展有关,p73α的阳性表达可作为乳腺癌临床TNM分期的一个指标。

Objective：To study the expression of p73a and its clinical significance in breast carcinoma. Methods：The expression of p73α was detected by immunohistochemistry in 41 breast carcinoma tissues, 13 benign breast tumor tissues and 8 normal breast tissues. Results ：The positive expression of p73α was found in 20/41 （48.8 % ） of breast carcinoma tissues, 1/13 （7.7 % ）of benign breast tumor tissues,0/8（0）of normal breast tissues. The positive expression rate of p73α in breast carcinoma tissues was significantly higher than that in benign breast tumor tissues or normal breast tissues（ P 〈 0.05 ）. P53 pcxsitive expression rate in breast carcinoma group was 48.8 % （20/41） ;p21 positive expression rate was 78 % （32/41） ;p73α expression displayed a positive correlation with p53 instead of p21. Significant associations were observed among the positive expression of p73α and tumor with lymph node metastases, TNM stages of the cancer（ P 〈 0.05 ）. Conclusion ：These results suggest that there is up - regulation of p73α in breast carcinoma tissues and up- regulation of p73α may be implicated in the tumorigenesis of breast carcinoma as a molecular alteration.