子宫颈病变电环切术后的临床疗效观察

Study on clinic curative effect of cervical intraepithelial neoplasia after LEEP conization

目的探讨宫颈病变患者行子宫颈电环切术(loopelectrosurgicalexcisionprocedure,LEEP)后的临床疗效。方法对宫颈薄层液基细胞学(liquid-basedcytologytest,LCT)、人乳头瘤病毒(humanpapillomavirus,HPV)检测阳性,阴道镜活检病理诊断为宫颈上皮内瘤样病变(cervicalintraepithelialneoplasia,CIN)Ⅰ58例、CINⅡ72例、CINⅢ95例(原位癌10例)患者行LEEP,切除组织标记后均行病理检查。结果LEEP术后3个月随访CINⅠ100%治愈,CINⅡ98.6%治愈,CINⅢ98.9%治愈,宫颈糜烂100%愈合,宫颈肥大89.8%完全恢复正常大小。术后6个月随访CIN100%治愈。术后3、6、9、12个月随访患者HPV检测转阴率显著,10例原位癌术后随访1年正常。结论LEEP术是目前临床上治疗宫颈病变的最有效方法。

Objective To study on clinic curative effect and post-operative following-up of cervical intraepithelial neoplasia （CIN） after LEEP conization. Methods All 225 cases with LCT-positive and HPV-positive in our centre from 2003 to 2004 were biopsy by colposcopy,and were diagnosed as cervical intraepithelial neoplasia. The cases were divided into 3 groups according to lesion grade, which was CIN Ⅰ （58）, CIN Ⅱ （72） and CIN Ⅲ （95）, and 225 patients were operated by LEEP. The samples of all LEEP operation were examined by pathology again. Results The curative rate of cervical erosion, cervical hypertrophy, CIN Ⅰ, CIN Ⅱ and CIN Ⅲ were 100%, 89.8%, 100%, 98,6% and 98.9% respectively on 3 month after LEEP operation. HPV of 225 cases was negative on 3, 6, 9, 12 month after operation.Ten patients with CIN Ⅲ were normal by LCT, HPV and colposcopy in one year.Conclusion LEEP operation is the most effective method for treatment of cervical lesion,