PHC患者血清AFP AFU SF联合检测的意义

THE COMBINED EXAMINATION OF AFP AFU AND SF CONTENTS IN THE SERUM OF PHC PATIENTS

目的探讨原发性肝癌(PHC)患者血清甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、铁蛋白(SF)联合检测的临床意义。方法利用化学发光免疫分析法和酶标记法对46例PHC患者、52例良性肝病患者、61例健康对照者血清AFP、AFU、SF含量进行检测,并对其结果进行分析。结果PHC患者组血清AFP、AFU、SF水平均显著高于良性肝病组及健康对照组,联合检测血清AFP、AFU、SF诊断肝癌的敏感性、特异性、准确性、阳性预测值、阴性预测值均显著高于各单项标志物检测。结论联合检测血清AFP、AFU、SF三项标志物对PHC的早期诊断具有重要的临床意义,可明显提高肝癌患者阳性诊断率。

Objective To explore the clinical value of the combined examination ot the contents of α-tetoprotein（AFP） ,AFU and serum ferritin （SF） in primary hepatic cancer （PHC）. Methods The contents of AFP, AFU and SF of 46 cases of PHC patients,52 cases of benign liver diseases and 61 healthy people were examined respectively through chemilumineseene. Results The contents of AFP, AFU and SF in PHC patients were found much higher than those of the group of benign liver diseases and the normal group. The conbined examination showed higher sensitivity, specificity, accuracy, positive prediction value and negative prediction value than the examinations of respective items. Conclusion The combined examination of AFP AFU and SF can provide early diagnoses and promote the diagnosis of positive cases of hepatic cancer.