CD44v6在胃癌中的表达及与胃癌生物学行为的关系

Metastatic adhesion molecule CD44 variant 6 and the pathobiological behavior of gastric cancer

目的:观察CD44v6在胃癌组织中的表达,探讨与胃癌生物学的关系。方法:对113例人胃癌组织标本进行ABC免疫组化检测。结果:CD44v6在早、中、晚期胃癌中的表达率分别为16.7%,25%和49.3%(P<0.01);无转移胃癌、伴淋巴结转移、伴肝脏转移胃癌的表达率分别为19.6%,48.3%和71.4%(P<0.05);肠型胃癌表达率44.0%明显高于弥漫型胃癌23.7%(P<0.01)。结论:CD44V6为判断胃癌病期进展和预测胃癌转移潜能的辅助生物学指标。

Objective： To investigate the expression of CD44v6 in gastric cancer and to evaluate its prognostic value. Methods：The expression of CD44v6 was analyzed immunohistochemically in gastric cancer by using monoclonal antibody. We investigated the relationship between CD44v6 expression and prognosis in 113 patients with gastric cancer.Results ：CD44v6 expressed in the membrane of cancer cells in 16.7％ （5/30） of EGC ,25％ （4/16） of MGC, and 49.3％ （ 33/67 ） of AGC （ P 〈 0.01 ）. CD44v6 was detected in 48.3％ （28/58） of patients with lymph node metastasis （Mets） and in 71.4％ （5/7） of those with liver metastasis, while only in 19.6％ （9/46） of those without any metastasis（ P 〈0.05 ）. Significantly more cases of intestinal-type gastric cancer had the expression of CD44v6 than diffuse-type cases （ P 〈 0.01 ）. Conclusion：CD44v6 protein may play an important role in progression and metastatic potential of gastric cancer, and may be a biologic marker of gastric cancer。