缬沙坦与阿托伐他汀联合治疗对高血压病人颈动脉内膜中层厚度的影响

EFFECT OF VALSARTA AND ATORVASTATIN ON INTIMA-MEDIA THICKNESS OF COMMON CAROTID ARTERY IN PATIENTS WITH HYPERTENSION

①目的比较观察缬沙坦联合阿托伐他汀应用与单用对原发性高血压病人颈动脉内膜中层厚度(IMT)的影响及临床意义.②方法选择86例Ⅰ、Ⅱ级高血压且血脂正常病人,随机分为两组,A组应用缬沙坦80 mg,每日1次;B组应用缬沙坦80 mg,每日1次,并阿托伐他汀10 mg,每日1次,治疗12周.治疗前、后超声测定IMT、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白-C(LDL-C).③结果治疗2周后血压已显著下降(t＝11.10～24.00,P＜0.01),12周后血压趋于稳定,两组的降压幅度无显著差别(t＝0.35～1.34,P＞0.05).与治疗前比较,A组IMT有显著降低(t＝2.04、2.65,P＜0.05),TC、TG、LDL-C无显著改变(t＝0.20～0.64,P＞0.05),B组TC、TG、LDL-C、IMT均显著降低(t＝2.83～14.10,P＜0.01),两组比较有显著差异(t＝2.53～7.34,P＜0.05).④结论缬沙坦联合阿托伐他汀应用与单用比较,对逆转原发性高血压病人颈动脉IMT的效果显著.

Objective To study the effects of valsarta combined with atorvastatin on intima-media thickness（IMT）of common carotid artery of patients with mild to moderate essential hypertension. Methods Eighty-six patients with mild to moderate essential hypertension and normal lipidemia were randomly divided into two groups. Group A was given Valsarta 80 mg qd;Group B, Valsarta 80 mg qd combined with atorvastatin 10 mg qd. Both were treated for 12 weeks. IMT, TC, TG,LDL-C were evaluated before and after the treatment. Results There was no difference in BP, TC, TG, LDL-C or IMT between the two groups before treatment. BP decreased significantly （t=11.10-24.00, P〈0.01）two weeks after administration and decrease till the end of experiment in both groups. TC, TG, LDL-C, IMT were decreased significantly（t=2.83-14. 10, P〈0.01） in Group B and IMT were decreased significantly （t=2.04,2.65; P〈0.01） in Group A after 12 weeks. The difference was significant between the two groups （t=2.53-7.34, P〈0.05）. Conclusion Valsarta combined with atorvastatin is more effective than Valsarta alone in IMT of the common carotid artery in the treatment of patients with mild to moderate hypertension.