水悬浮体系中α,β-环氧酮类化合物的合成研究

Synthesis of α,β-Epoxy Ketones in a Water Suspension Medium

在水悬浮体系中使用三氯异氰尿酸/碱氧化体系对α,β-不饱和酮化合物进行环氧化和对烯丙基醇类化合物进行直接氧化-环氧化制备α,β-环氧酮,考察了表面活性剂、碱等因素对反应的影响.反应无需有机溶剂,对于大部分的烯酮和烯丙基醇反应可以在数小时内完成,产率良好.

Trichloroisocyanuric acid-base can be used as an efficient oxidant for the epoxidaiton of enones and tandem oxidation-epoxidation of allylic alcohols in a water-suspension system as completely organic solvent free reactions. The effects of surfactant and base have been investigated. For most of the enones and allylic alcohols, the reaction could be completed within several hours with good yields.