α-取代氨基氟代苯基膦酸酯衍生物的合成、晶体结构与抗癌活性

Synthesis, Structure and Antitumor Activity of α-Substituted Aminofluoroarylphosphonate Derivitaves

利用席夫碱与亚磷酸酯反应,合成了新型O,O'-二烷基-α-(6-甲氧苯并噻唑-2-基氨基)-4-氟苯基膦酸酯化合物,结构经元素分析,IR,1HNMR,13CNMR和X单晶衍射确认.X单晶衍射测试结果表明:化合物3d分子属于四面体晶系,空间群I4(1)/a,a=2.1055(3)nm,b=2.1055(3)nm,c=2.0521(5)nm,α=90.00°,β=90.00°,γ=90.00°,V=0.9098(3)nm3,Z=16,Dc=1.321mg/m3,μ=0.250mm-1,F(000)=3808.化合物还存在着1个分子内氢键[N(2)—H(2)…O(1)].生物测定表明化合物3f在20μg/mL浓度下对PC3细胞的抑制率为84.3%.

Some novel O,O′-diakyl-α-（6-methoxybenzothiazol-2-ylamino）-4-fluorophenylphosphonates （3） have been synthesized through the reaction of Schiff base with dialkyl phosphite. Their structures were clearly established by elemental analysis, IR, 1H NMR, 13C NMR and X-ray diffraction analysis. The crystal of compound 3d belongs to tetragonal with space group I4（1）/α,α-=2.1055（3）nm, b=2.1055（3） nm, c=2.0521（5） nm, α=90.00°, β=90.00°,γ=90.00°, V=0.9098（3） nm^3, Z=16, Dc=1.321 mg/m^3,μ=0.250mm^-1, F（000）=3808. There exists an intramolecular hydrogen bond [N（2）-H（2）…O（1）] in the molecule of 3d. Bioassay tests showed that compound 3f could inhibit PC3 cell proliferation at the concentration of 20μg/mL with the inhibition rate 84.3%.