α-(1,3,4-噻二唑-5-基)氨基烃基膦酸酯的合成及生物活性

Synthesis and Biological Activity of α-(1,3,4-Thiadiazol-5-yl)-aminoalkyl Phosphonates

以5-氨基-2-巯基的席夫碱与亚磷酸二乙酯反应,合成了15个新的α-(1,3,4-噻二唑-5-基)氨基烃基膦酸酯,初步的生物活性测试表明部分目标化合物具有较好的植物生长调节活性,其中2,4-二氯苯甲醛、呋喃甲醛和吲哚甲醛的席夫碱生成的α-氨基烃基膦酸酯具有较好的生长素活性.

Fifteen new α-（1,3,4-thiadiazol-5-yl）aminoalkyl phosphonates have been synthesized by addition reaction of diethyl phosphite to the corresponding Schiff bases of 5-amino-2-mecapto-l,3,4-thiadiazole.Preliminarily biological activity tests show that some target compounds have good activity as plant growth regulator, particularly α-aminoalkyl phosphonates of 2,4-dichlorobenzaldehyde, furfuraldehyde and indolylaldehyde have better auxin activity.