维吾尔族高血压病患者血浆内皮素与神经降压素水平变化的研究

Changes of plasma endothelin and neurotensin in Vighur patients with essential hypertension

目的:探讨维吾尔族高血压病(EH)患者血浆内皮素(ET)、神经降压素(NT)水平与EH的关系。方法:采用放免法检测76例EH患者(维吾尔族32例,汉族44例)及健康人64例(维吾尔族34例,汉族30例)血浆ET及NT的含量。结果:①EH患者ET水平较健康组显著升高(P<0.05);②维吾尔族健康组ET水平明显低于汉族(P<0.05),但两民族EH组间未发现有差异;③EH组与对照组间及两民族间NT差别均无显著性。结论:EH患者ET水平较对照组明显升高,维吾尔族健康人群低于汉族,提示ET可能与EH的发病有关。NT与EH的关系有待进一步研究。

To investigate the effect of plasma endothelin（ET） and neurotensin（NT） in Vighur patients with essential hypertension. Methods： Seventy - six patients with essential hypertension （ systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥90 mmHg） and 64 healthy controls were enroUed, including 32 Vighur w vand 44 Han patients ; 34 Vighur and 30 Han healthy controls. ET and NT levels were measured by radioimmunoassay. Results：① The ET concentration of EH patients were significantly higher than those in healthy group （P 〈0.05 ）. ② Compared with Han, ET of Vighur healthy group was significantly lower （ P 〈 0.05）. ③Though NT of EH patients was lightly lower than that in healthy group, NT in Vighur was lightly higher than that in Han people, there were no significant difference （P 〉 0. 05 ）. Conclusion： ①ET in hypertension patients was significantly higher than those in healthy group. It indicated that ET may participate in the constitution of hypertension. ② The Vighur healthy people has a lower hypertension incidence rate of ET than that in Han. ③ As for NT, there was no difference between the two races, between the patients and the healthy people.