摘要
目的探索联苯乙酸的一种新的合成方法。方法以苯硼酸和对溴苯乙酸乙酯为起始原料,经偶联、皂化二步反应得目标化合物。结果化合物的结构经IR1、HNMR分析确证。结论合成路线较短,反应条件温和、易控制,二步总收率达78%,是合成该目标化合物的一种较为理想的方法。
OBJECTIVE To study a convenient synthesis of Felbinac. METIFIODS The title compound was synthesized via 2 steps starting from phenylboronic acid and ethyl p- bromophenylacetate. RESULTS The structures of compounds were confirmed by spectral data of IR and ^1HNMR. CONCLUSION The method is convenient with mild condition,and the overall yield is 78%.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2005年第4期320-321,共2页
West China Journal of Pharmaceutical Sciences
关键词
联苯乙酸
苯硼酸
合成
Felbinac
Phenylboronic acid
Synthesis
