冰片注射液对小鼠实验性脑缺血的保护作用

Effects of Borneol injection on experimental cerebral ischemia in mice

目的研究冰片注射液对小鼠实验性脑缺血的保护作用及机制。方法分别采用小鼠结扎双侧颈总动脉及迷走神经模型、常压耐缺氧模型、大脑中动脉阻塞(MCAO)模型,记录此后小鼠的存活时间,并对大脑中动脉阻塞小鼠进行行为学评分、测量其脑梗死面积,计算脑指数。结果冰片注射液可延长小鼠结扎双侧颈总动脉及迷走神经、常压耐缺氧后的存活时间,提高MCAO小鼠行为学评分,降低脑梗死面积及脑指数。结论冰片注射液对小鼠实验性脑缺血具有保护作用,其机制可能与改善缺血脑组织内能量代谢有关。

OBJECTIVE To investigate the protective effects of Bomeol infection against cerebral ischemia in mice and its mechanism. METHODS Mice models subjected to bilateral ligation of common carotid with vagus nerves, normobaric hypoxia and middle cerebral artery occlusion（MCAO） were used, to study the survival time of mice. The effect of Bomeol on neurological deficit and the ratio of right/left cerebral hemisphere areas, infarct size in mice with middle cerebral artery occlusion. RESULTS Bomeol could significantly prolong the survival time of mice. The score of neurological deficit, the ratio of right/left cerebral hemisphere areas and infarct size were significantly decreased as compared with control group. CONCLUSION Bomeol may have a beneficial effect for the treatment of cerebral ischemic damage and its mechanism may be related to improvement of the energy metabolism.