固体脂质纳米粒的研究进展

Research and development of solid lipid nanoparticles

目的综述固体脂质纳米粒的最新研究进展。方法以国内外大量有代表性的论文为依据,将固体脂质纳米粒的制备方法、特性分析、药物载入、药物释放及应用情况进行了概括,指出了发展前景和尚待解决的问题。结果固体脂质纳米粒的多种制备方法各有优、缺点,调整制备参数可调整药物的包封率和释药曲线。结论固体脂质纳米粒可供多途径给药,是极有发展前景的新型给药系统。

OBJECTIVE To review the latest research development of the solid lipid nanoparticles（SLN）. METHODS According to the recent relevant literature, the preparations for the SLN, characterization analysis, drug incorporation, drug release, and its application in the pharmaceutical field were summarized. Its development prospect and unsolved problem were pointed out . RESULTS Each preparations of the SLN has advantages and disadvantages. The drug incorporation and release profiles could be modified as adjustment of production parameters. CONCLUSION The SLN could be used by various administration, and they have broad prospects in the pharmaceutical field.