摘要
目的观察乳酸亚铁片治疗缺铁性贫血(IDA)的疗效和不良反应。方法采用随机对照的试验方法,将乳酸亚铁治疗IDA的疗效及不良反应与琥珀酸亚铁进行比较,疗程6周。结果乳酸亚铁片治疗4周的显效率、有效率及总有效率分别为72.41%、17.24%和89.65%,而琥珀酸亚铁的则分别为54%、22%和76%,前者疗效优于后者(P<0.05),显示乳酸亚铁片治疗IDA见效较琥珀酸亚铁快;乳酸亚铁治疗IDA6周的显效率及有效率分别为93.05%和2.78%,而琥珀酸亚铁的则分别为93.44%和4.92%,无统计学差异(P>0.05),显示两药治疗6周的疗效基本相同。两药不良反应比较无明显差异(P>0.05)。结论乳酸亚铁片治疗IDA疗效好,胃肠不良反应轻,患者耐受性好,是治疗IDA安全、有效的口服铁剂。
OBJECTIVE To study the treatment effectiveness and side effects of Ferrous Lactate tablets for the patients with iron deficiency anemia (IDA). METHODS A randomized clinical trial was performed to compare the treatment effectiveness and side effects of Ferrous Laerate tablets with Ferrous Succinate tablets on patients with IDA orally taken for 6 weeks. RESULTS On the forth week of the trial, renarrkably effeetive rate, effective rate and totally effective rate of ferroas lactate and ferrous succinate were 72.41%, 17.24 %, 89.65 % and 54%,22%,76%, respectively. The effectiveness of ferrous lactate was higher than that of ferrous succinate (P 〈 0.05). The remarkahly effective rate and effective rate of ferrous lactate and ferrous sueeinate on the sixth week of the trial were 93.05%, 2.78% and 93.44%, 4.92% , respectively. The effectiveness of two drugs was the ,same( P 〉 0.05). while the side effects of both drugs were no difference ( P 〉 0.05). CONCLUSION Ferrous Lactate tablet is a highly effective drug as Ferrous succinate tablets and with endurably mild side effects to patients with IDA.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2005年第4期367-370,共4页
West China Journal of Pharmaceutical Sciences
关键词
乳酸亚铁片
琥珀酸亚铁
缺铁性贫血
Ferrous lactate
Ferrous succinate
Iron deficiency anemia