扁平苔藓患者血小板聚集和血液流变学研究

Research on platelet aggregation and hemorrheology of oral lichen planus

目的:研究口腔扁平苔藓(OLP)发作期、稳定期和消退期的血小板聚集和血液流变学变化,探讨OLP微循环障碍和炎症反应的机制。方法:观察65例OLP发作期、治疗后稳定期和消退期的血小板聚集和血液流变学指标的变化,与30例健康志愿者进行对照。结果:OLP发作期、治疗后稳定期和消退期的血小板聚集率(1min、3min和最大聚集)明显增强(P<0.01),全血粘度(低切、高切)、血浆粘度、红细胞压积、血沉和红细胞聚集指数、纤维蛋白元等血液流变学指标均高于对照组(P<0.05)。且发作期的指标高于治疗后稳定期和消退期。而红细胞刚性指数、红细胞变形指数变化明显。结论:OLP患者的血小板聚集和血液流变学指标增强,提示OLP的发病机制和疾病演变与血小板聚集和血液流变学改变有关。

Objective：To investigate the pathogenesis of platelet aggregation and hemorrheology on oral lichen planus （OLP）. Method： by survey platelet aggregation and hemorrheology on activeduty and relaxation of the 65 patients with OLP （25-65 years old） were studied,and the 30 nomal for contrast group . Result.On activeduty and relaxation of the 65 patients with OLP, platelet aggregation （1,3, 5 minute and the most） are significantly increased （P〈0. 01）. The whole blood viscosity, plasmatic viscosity , Erythrocyte Express Amass , ESR , Erythrocyte Aggregation Exponent and were markedly increased （P 〈 0.05 ）, which had statistical significance compared with the control group. On activeduty are significantly increased compared with relaxation. The Erythrocyte Rigidity Exponent, Erythrocyte Deformation Exponent were markedly chang. Conclusion. This results suggested that OLP is involved in many factors, platelet aggregation and hemorrheology are realeated with activeduty and relaxation , and play an important role in pathogenesis of OLP.