化学治疗对乳腺癌转移患者疼痛的治疗效果

Analgesic Effect of Chemotherapy for Pain Control in Breast Cancer with Metastases

目的探讨化学治疗对乳腺癌转移患者疼痛的治疗效果。方法对37例伴有中度和重度疼痛的乳腺癌转移患者分别采用CMF、CAF或TA(泰素、阿霉素)等方案化疗并评价镇痛疗效。结果37例中21例(56.8%)疼痛完全缓解,16例(43.2%)疼痛部分缓解,总疼痛缓解率100.0%。肿瘤PR13例中疼痛完全缓解11例(84.6%),而肿瘤SD24例中10例疼痛完全缓解(41.7%),肿瘤PR与肿瘤SD者的疼痛完全缓解率比较有显著差异(χ2=6.33,P<0.05)。结论化疗对乳腺癌转移患者的疼痛治疗有显著疗效,化疗镇痛作用与肿瘤客观疗效密切相关,化疗应成为乳腺癌转移患者疼痛的首选治疗。

Objective To identify analgesic effect of chemotherapy for pain control in breast cancer with metastases. Methods A total of 37 patients with moderate and severe pain due to breast cancer with metastases were treated by chemotherapy including CMF,CAF or TA regimens. The analgesic effect of chemotherapy was assessed. Results Complete pain relief was achieved in 56.8% （21/37） of patients,partial pain relief in 43.2% （16/37） of patients. The overall pain relief rate was 100.0%. Complete pain relief rates were 84.6 % （11/13） in patients with partial response and 41.7 % （10/24） in patients with disease stabilization, showing a significant difference between them（x^2= 6.33,P〈 0.05）. Conclusion Chemotherapy is effective for pain relief due to breast cancer with metastases and can be the best choice for the pain control. The analgesic effect is closely associated with the effect on tumor regression.