CTn-I RIA对急性心肌梗塞诊断价值的评价

The Value on Cardiac Troponin I Assessed by RIA for the Diagnosis of Acute Myocardial Infarction

以心肌肌钙蛋白1放射免疫分析法（CTn－IRIA）测定急性心肌梗塞（AMI）35冽，非心肌梗塞（NMI）60例和正常健康人37例血清CTn－I的浓度，结果AMI组4．06±0．09ug／L（±s）明显高于后两组（P＜0．01），正常组为2．04±0．13ug／L，单侧95％可信上限界为3．35ug／L，以＞3.35ug/L为阳性.AMI组阳性率为94.3％，骨骼肌损伤18倒无1例阳性。提示CTn－I特异地存在于心肌中。按林氏推荐的公式[1]评价本方法对AMI的诊断价值阳性结果为90．41％，阴性结果为99.04％，准确率达92.15%,且CTn-I在AMI一周内为阳性。

We useded Cardiac Troponin I Radioimmuoassy (CTn-IRIA) to measure CTn-I concentration in a cute Myocardial infarction (AMI) 35 cases. non-mycocardial infarction (NMI) 60 cases and 37 cases of healthy men. Value of CTn-I in AMI were 4.061±0.09 ug/L(±s). It was more than that in NMI and healthy men (P<0.01). Normul value was 2.04±0. 13 ug/L. The upper limit was 3. 35 ug/L (nonparametric 95% interval), >3. 35 ug/L as positive, the positive rate for AMI was 94. 3%. All patients with injury of skeletad musule were negative. This showed that CTn-I is specificic in myocardial damage. According to ling's formula, the positive and negative diagnostic value for AMI is 90. 4% and 94. 04% respectively by this CTn-I assay, and its overall accuracy rate is 92. 15%. lt has been observed that CTn-I is still increased by the end of onset of AMI after one week.