美托洛尔治疗扩张型心肌病心衰的研究

Study of Metoprolol in the Treatmert of Congestive Heart Failure from Dilated Cardiomyopathy

为观察美托洛尔长期治疗扩张型心肌病（DCM）心衰的疗效，探讨其作用机理，选10例心功能Ⅱ～Ⅳ级的DCM患者，美托洛尔平均剂量26．25±13．76mg／天，治疗时间为5．4±2．07个月。治疗后心功能改善，血浆去甲肾上腺素及异丙肾上腺素敏感试验ICD25下降小周血淋巴细胞β受体无改变。DCM心功能改善的可能机制是通过阻滞交感神经系统的过度兴奋及上调心肌β受体而实现。

To study metoprolol in the treatment of congestive heart failure from dilated cardiomyopathy (DCM) and it's mechanism, 10 patients with DCM werr enrolled in our study. For NYHA function class Ⅱ ~ Ⅳ，Metoprolol dose was 26. 25±13. 76 mg given daily, follow-up time was 5. 412. 07 months. At the end of follow-up time, cardiac function improved, plasma norepinephrine and isoprenaline sensitivity test ICD25, became decreased,while circulating lymphocyte B-adrenergic receptor number was unchanged. The improvement of cardiac function is probably due to blocking up excitement of sympathetic system and enhancing the response of cardiac B-recepter.