苯妥英钠血药浓度与下肢运动障碍的关联

Phenytoin Poisonings Resulting in an Impediment to Leg Activity

目的:考察苯妥英钠中毒浓度与下肢运动障碍间的相关性。方法:收集苯妥英钠血清浓度监测结果,并与下肢运动障碍间关系进行统计学分析。结果:苯妥英钠血清浓度≥30mg·L-1时,下肢运动障碍与苯妥英钠中毒浓度相关,有显著性意义(Fisher确切概率法检验,P=0.000)。结论:30mg·L-1为下肢运动障碍阈值,苯妥英钠中毒浓度≥30mg·L-1可致下肢运动障碍,为临床诊断苯妥英钠中毒提供了新的依据。

Objective： To study the correlation between phenytoin poisoning and the impediment to leg activity. Method ： The results of phenytoin in serum were collected and statistically compared with the impediment to leg activity, Result： When the concentration of pbenytoin in serum was more than 30 mg·L^-1 , the correlation between them was significant （F-test, P=0. 000）. Conclusion： Phenytoin poisoning may result in an impediment to leg activity, which provides a new evidence for the clinical diagnosis of phenytoin poisoning,