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巢式甲基化特异性PCR检测肺癌患者基因异常甲基化 被引量：2

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作者 姚群峰 张利平 宁勇 曾卫 周宜开
机构地区 湖北中医学院医学检验与技术系
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2005年第15期894-895,共2页 Chinese Journal of Clinical Oncology
基金 湖北省教育厅重点研究项目基金资助(编号:2003x028)
关键词 MGMT基因 巢式甲基化特异性PCR 肺癌
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1Bird AP. CpG-rich-island, and the function of DNA methylation1[J]. Nature, 1986, 321(6067):209～213.
  • 2Esteller M, Hamilton SR, Burger PC, et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia[J]. Cancer Res, 1999, 59(4):793～797.
  • 3Esteller M, Toyota M, Sanchez-Cespedes M, et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis [J]. Cancer Res, 2000,60(9):2368～ 2371.
  • 4Geady WM, Rajput A, Lutterbough JD, et al. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer [J]. Cancer Res,2001, 61(3):900～902.
  • 5Herman JG, Graft JR, Myohanen S, et al. Methylation-specific PCR: a novel PCR assay for methylation status of GpG islands[J].Proc Natl Acad Sci USA, 1996, 93(18):9821～9826.
  • 6Palmisano WA, Divine KK, Saccomanno G, et al. Predicting lung cancer by detecting aberrant promoter methylationin sputum[J].Cancer Res, 2000, 60(21):5954～5958.
  • 7Esteller M, Com PG, Baylin SB, et al. A gene hypermethylation profile of human cancer[J]. Cancer Res, 2001, 61(8):3225～3229.
  • 8Belinsky SA, Nikula KJ, Palmisano WA, et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis [J]. Proc Natl Acad Sci USA,1998, 95 (20) :11891 ～ 11896.

同被引文献15

  • 1徐昊平,金冶宁.食管癌肿瘤细胞放疗后加速再增殖及相关治疗[J].现代肿瘤医学,2007,15(8):1194-1196. 被引量：5
  • 2Siegel R, MaJ, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin, 2014,64(1): 9-29.
  • 3Zochbauer-Muller S, Fong KM, Virmani AK, et al. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res, 2001,61(1): 249-255.
  • 4Brabender J, Usadel H, Metzger R, et al. Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome. Clin Cancer Res, 2003, 9(1): 223-227.
  • 5Guo M, House MG, Hooker C, et al. Promoter hypermethylation of resected bronchial margins: a field defect of changes. Clin Cancer Res, 2004,10(15): S131-5136.
  • 6Russo AL, Thiagalingam A, Pan H, et al. Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression oflung cancer. Clin Cancer Res, 2005, 11(7): 2466-2470.
  • 7Topaloglu 0, Hoque MO, Tokumaru Y, ei al. Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin Cancer Res, 2004, 10(7): 2284-2288.
  • 8Begum S, Brait M, Dasgupta S, et al. An epigenetic marker panel for detection ofIung cancer using cell-free serum DNA. Clin Cancer Res, 2011,17(13): 4494-4503.
  • 9Safar AM, Spencer H 3rd, Su X, et al. Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res, 2005,11(12): 4400-4405.
  • 10Zhang Y, Wang R, Song H, et al. Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. Cancer Lett, 2011, 303(1): 21-28.

引证文献2

二级引证文献3

中国肿瘤临床
2005年 第15期

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